Abstract

Forced degradation is a process that involves degradation of drug products and drug substances at conditions more severe than accelerated conditions and thus generates degradation products that can be studied to determine the stability of the drug molecules. Five different brands of Ceftriaxone injection were collected from the market and exposed to various stress condition like alkaline, acidic, oxidative and thermal degradation. The degradation process was followed by using spectrophotometric analysis. All the antibiotic brands undergo forced degradation at conditions in different ranges and the maximum degradation observed in the basic medium.