Abstract

    The aim of the present study was to investigate the ability of Sider honey to protect renal from the toxic effect of tetrachloride (CCl₄) in Male Rabbits. For obtaining the aim of this study, thirty local breed male rabbits (weighted 1000-1400 gr) were used. The animals were divided into five groups, every group contains (6) animals, The first group served as control animals, and they orally received only 5ml of dis water once a day for a period of 30 days .The second group was i.m injected by (1ml/kg) of CCl₄ twice a week in order to induce the toxicity in renal, then they had not received any treatment for a period of 30 days. The third group was i.m injected by 1ml/kg of CCl₄ twice a week and then orally received a 1g/kg of honey dose daily for a period of 30 days. The fourth group of animals was i.m injected by 1ml/kg of CCl₄ a twice-in week and then orally received 2g/kg of honey dose daily for a period 30 days. The fifth group received 2g/kg of honey for a period of 15 days , in day 16^th  ,they were i.m injected by 1ml/kg of CCl₄ twice week in order to induce the toxicity in renal , with the continuation of receiving the dose of honey until day thirty.
      The values of Urea, Uric acid, Creatinine in serum of blood were estimated. The results showed a highly significantl in P< 0,05 increase in level of urea , uric acid creatinine was shown in group 2. Our results emphasized the high toxicity of CCl₄. Let the use of honey as curative and protective agent to protect the toxic effect of CCl₄, and decrease the level of urea, uric acid, creatinine in serum animals. The best results was recorded in 5^thgroup animals that received 2g/kg of honey as protective agent.