Abstract

Prostatic diseases are responsible for significant morbidity and mortality among adult males worldwide. Most frequently encountered diseases affecting prostate are prostatitis, benign prostatic hyperplasia (BPH) and prostatic cancer.
Paraffin blocks of prostatic tissues of 694 biopsies were selected retrospectively, from the private laboratories in Aden governorate – Yemen from January 2010 – March 2015. Hematoxylin and eosin slides for the corresponding paraffin-embedded formalin-fixed blocks were examined to identify and confirm the presence and type of inflammation in benign prostatic lesions, prostatic intraepithelial neoplasia and carcinoma. Data were entered to the SPSS program (version 22), obtaining frequencies, percentages and chi-square tests. The risk of malignancy associated with inflammation was estimated compared to those having non-inflammatory prostatic lesions. The tests were conducted with the 95% confidence interval and p-values of ≤ 0.05 were considered statistically significant.
Inflammation was found commonly in benign prostatic hyperplasia{78.2%}, in prostatic intraepithelial neoplasia {7.7%} and prostate cancer (92.3%}, most of which was chronic(p<0.001).The risk for malignant transformation was2.98 times. Moderate, multifocal and stromal chronic inflammatory infitration was commonly seen in benign prostatic lesions. High grade prostatic cancer was observed in men who had inflammation.
Our findings revealed that chronic inflammation is a common finding in benign(particularly bengin prostate hyperplasia) and malignant prostate tissue among yemeni people. Chronic inflammation, in benign prostate tissue is associated with an increased risk of prostate cancer (>two folds).