Abstract

     The aim of this study is to investigate the effect of honey and Aqueous crude extract of leaves Aloe vacillans  on carbon tetrachloride (CCl₄)- induced hepatotxicity in rabbits.

Hepatotoxicity was induced in rabbits by intraperitoneal injection of (CCl₄) 0.2 ml/kg of body weight on day 19, 20 and  21.  The aqueous crude extract of Aloe vacillans leaves were administrated at dose 100 mg, 300 mg and 500 mg/kg of body weight pass orally ( p.o) daily for 28 days. The hepatotoxicity was induced in rabbits by intraperitoneal injection of (CCl₄) 0.2 ml/kg of body weight on day 19, 20 and  21.

The honey were administrated at dose 500 mg/kg of body weight pass orally (p.o) daily for 28 days. The hepatotoxicity was induced in rabbits by intraperitoneal injection of (CCl₄) 0.2 ml/kg of body weight on day 19, 20 and  21.                             

    The hepatotoxicity and its prevention was assessed by serum parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin (Bil) and total  protein (T.P). In CCl₄ treated rabbits, a significant, increasing the in (ALT) ,(AST) , bilirubin and a decreasg the total protein levels were shown at (p<0.05), due to liver damage, when compared with normal group.

     Treatment with the aqueous extract of Aloe vacillans could significantly decrease the (ALT),(AST) and bilirubin, increased T.P in serum at p< 0.05 when compared with CCl₄ –treated group.Treatment honey at dose (500 mg/kg) could significantly decrease the (ALT),(AST) and bilirubin, increased T.P in serum at p< 0.05 when compared with CCl₄ –treated group and the aqueous extract of aloe treated groups.

     The data suggested that oral administration of Honey and aqueous extract of the leaves of  Aloe vacillans at dose (500 mg/kg) significantly decreases the intensity of hepatic damage induced by CCl₄ in rabbits.